Roslin 2 bromide

Research use only, not for human use.

Roslin 2 bromide is a p53 reactivator that disrupts the binding of FAK and p5Roslin 2 bromide exhibits anticancer effects.

Roslin 2 bromide is a p53 reactivator that disrupts the binding of FAK and p5Roslin 2 bromide exhibits anticancer effects.(In Vitro):Roslin 2 bromide decreases cancer cell viability and clonogenicity in a p53-dependent manner.(In Vivo):Roslin 2 bromide (60 mg/kg; i.p) significantly decreased tumor growth, disrupts the complex of FAK and p53, and up-regulated p21 in HCT116 p53+/+ but not in HCT116 p53-/- xenografts.

Roslin 2 bromide decreases cancer cell viability and clonogenicity in a p53-dependent manner. Roslin 2 bromide increases p53 transcriptional activity that is inhibited by FAK using p21, Mdm-2, and Bax-promoter targets. Roslin 2 bromide also causes increased expression of p53 targets: p21, Mdm-2 and Bax proteins.

Roslin 2 (60 mg/kg; i.p; 5 days/week) bromide significantly decreases tumor growth, disrupts the complex of FAK and p53, and up-regulates p21 in HCT116 p53+/+ but not in HCT116 p53-/- xenografts in vivo.

Benzylhexamethylenetetramine bromide

Angiogenesis

FAK

Human Endogenous Metabolite|Drug Metabolite|Parasite|Purine nucleoside phosphorylase

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29574-21-8

311.227

C13H19BrN4

>98% (HPLC)

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[Br-].C(c1ccccc1)[N+]12CN3CN(CN(C3)C1)C2

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(-20℃)

With Ice Pack

≥ 2 years